Dietary fat source induces gut microbiota alterations and impacts chronic murine graft- versus-host disease severity

Abstract It has been observed that a constriction of the gut microbiome occurs with high fat diet, and likewise decreased diversity is directly correlated more severe graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation. Taken together it plausible not only content, but source dietary could influence microbiota GvHD outcome. We sought to address this question developed experimental rodent diets have same content (25% kcal fat, moderate increase in from normal chow) which differ by source: animal- versus plant-derived found these drive alterations diversity. Both yielded similar outcomes an acute model GvHD, however we mice fed animal-derived diet exhibited worse survival chronic than diet. These findings increased inflammation intestinal immune populations induction. Collectively, our data show are equal macronutrient different can promote microbiomes turn alter homeostasis Century for Cure - Philanthropic Fund